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Watch the Full Video at https://www.jove.com/v/59653/brain-in.... Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping - a 2 minute Preview of the Experimental Protocol J. Matthijs Biesbroek, Hugo J. Kuijf, Nick A. Weaver, Lei Zhao, Marco Duering, , Geert Jan Biessels Utrecht University, Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht; University Medical Center Utrecht, Image Sciences Institute; BrainNow Research Institute,; LMU Munich, Institute for Stroke and Dementia Research, University Hospital; Provided here is a practical tutorial for an open-access, standardized image processing pipeline for the purpose of lesion-symptom mapping. A step-by-step walkthrough is provided for each processing step, from manual infarct segmentation on CT/MRI to subsequent registration to standard space, along with practical recommendations and illustrations with exemplary cases. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments