Hereditary Cancer Explained: p53, RB, APC, and Genetic Risk Syndromes скачать в хорошем качестве

Hereditary Cancer Explained: p53, RB, APC, and Genetic Risk Syndromes

Explore the genetic basis of cancer in this comprehensive Chapter 7 lecture—perfect for students of oncology, genetics, nursing, and medical science. This video explains how inherited mutations increase cancer risk: Hereditary vs. Environmental Cancer: 80–90% of cancers are environmental; 10–20% have a hereditary basis Hereditary cancers involve mutations passed through families, affecting tumor suppressor and DNA repair genes Key Cancer Genes and Syndromes: Retinoblastoma (RB): Childhood eye cancer; RB gene mutation on chromosome 13 Two-Hit Hypothesis: Explains timing and inheritance differences in familial vs. sporadic cancers APC and FAP: Mutation in APC gene leads to Familial Adenomatous Polyposis (hundreds of colon polyps) Li-Fraumeni Syndrome: Inherited p53 mutation; increases risk for breast, brain, and sarcomas Tumor Suppressor Categories: Gatekeepers: Control proliferation (e.g., RB, APC, p53) Caretakers: Maintain genome integrity (e.g., mismatch repair genes) Genomic Instability Disorders: Xeroderma Pigmentosum (XP): Recessive disorder with UV sensitivity and high skin cancer risk HNPCC (Lynch Syndrome): Mismatch repair gene defects → colorectal and endometrial cancer Genetic Testing and Risk Management: Dominant vs. recessive inheritance patterns affect risk levels and family history importance Early genetic counseling, screening, and intervention can significantly reduce cancer development This lecture connects cancer biology with human genetics to help learners understand how inherited mutations drive cancer risk. Subscribe for more high-yield lectures in medical genetics, pathophysiology, and oncology. #HereditaryCancer #p53 #RB #APC #GeneticRisk #Retinoblastoma #LynchSyndrome #TumorSuppressorGenes #OncologyLecture #MedicalEducation #PathophysiologyLecture #CancerGenetics #XerodermaPigmentosum #LiFraumeniSyndrome