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Yelena Janjigian, MD, Memorial Sloan Kettering Cancer Center, New York, NY, presents the results of the randomized, double-blind, Phase III COMPASSION-15 trial (NCT05008783). The study showed that administering cadonilimab, an anti-PD-L1 and CTLA-4 bispecific antibody, resulted in a promising response rate in patients with unresectable locally advanced or metastatic gastric cancer. These findings suggest that the dual PD-L1 and CTLA4 blockade can be targeted safely in combination with chemotherapy. Dr Janjigian concludes that a follow-up and efficacy study is required in the Western patient populace, with a comparator cohort other than chemotherapy, such as nivolumab. This interview took place at the 2024 American Association for Cancer Research (AACR) in San Diego, CA. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.