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Tau phosphorylation Creative Diagnostics

Tau is a highly soluble protein that mainly expressed in the neurons in the central nervous system. Firstly discovered as a microtubule-associated protein, Tau protein is primarily found in axons where it regulates microtubule polymerization and promotes microtubule stabilization. However, via the selective binding of diverse partners, Tau participates in multiple physiological processes including regulation of axonal diameter and growth, regulation of vesicle and organelle transport, modulation of signaling cascades by acting as a protein scaffold, cellular response to heat shock, adult neurogenesis and the establishment of neuronal polarity in development. Otherwise, abnormal Tau functions are deeply involved in neurodegenerative diseases such as Alzheimer’s disease.