Tip-139;Cervical Adenocarcinoma, HPV-associated скачать в хорошем качестве

Tip-139;Cervical Adenocarcinoma, HPV-associated

Tip-139; Adenocarcinoma, HPV-associated, is an epithelial tumor forming glands with stromal invasion and/or exophytic expansile-type invasion, associated with high-risk HPV infection. It accounts for approximately 5% of all cervical carcinomas in non-screened populations. However, the relative prevalence of adenocarcinoma has increased to 10–25% of all cervical carcinomas in screened populations. The mean patient age at presentation is 40–42 years. In examples with destructive stromal invasion as in this case, there are poorly formed angulated glands and cellular clusters that haphazardly infiltrate the cervical stroma, with an accompanying desmoplastic stromal response. Morphologically, the nuclei are enlarged, elongated, and hyperchromatic, and the glands show smooth luminal borders lined by pseudostratified columnar epithelium. The morphological hallmarks of HPV-associated endocervical adenocarcinoma architecture include apical mitoses and basal apoptoses, which are conspicuous and identifiable at low-power magnification.  p16 immunohistochemistry is an effective indirect test for HR-HPV infection. Approximately 95% of HPV-associated carcinomas show diffuse block-type or every-cell staining/ overexpression.