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Alexander Coltoff, MD, Medical University of South Carolina, Charleston, SC, discusses his talk on the role of fedratinib, the second JAK inhibitor approved in myelofibrosis (MF), in 2024 and beyond. Dr Coltoff suggests that the agent is sometimes forgotten about, despite its efficacy in ruxolitinib-resistant patients and in the frontline setting. Fedratinib inhibits BRD4 and is being studied in combination with other agents for the treatment of several hematological malignancies. This interview took place at the 1st Annual MPN Workshop of the Carolinas in Asheville, NC. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.