Tip-85;Low-grade Appendiceal Mucinous Neoplasm (LAMN) скачать в хорошем качестве

Tip-85;Low-grade Appendiceal Mucinous Neoplasm (LAMN)

Tip-85; Mucinous neoplasm of the appendix is characterized by mucinous epithelial proliferation with extracellular mucin and pushing tumor margins. Patients can present with features of appendicitis. The classic pattern is replacement of the normal appendiceal mucosa by a villous mucinous epithelial proliferation. There is mild atypia reminiscent of low-grade colonic dysplasia at most. There is no lymphoid follicles as in a normal appendix. Fibrosis, hyalinization, and calcification are seen in the wall of the appendix. LAMN is considered in situ (pTis) if confined to the submucosa and muscularis propria. Mucin and/or epithelial cells that involve peritoneal surfaces beyond the appendix are staged as pM1a if the mucin is acellular and pM1b if the mucin contains mucinous epithelial cells. hyperthermic intraperitoneal chemotherapy (HIPEC) together with complete cytoreduction appears to be associated with excellent outcomes.