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How long have cosmetic filler injections been around in plastic surgery? And what was the very first injectable filler used to fix deformities of the nose, and fill the cheeks, lips, and rest of the face? In this episode of Aesthetic Minutes, we travel way back in time into the 1800's to learn of the earliest forms of injectable fillers, focusing on the very first widely use product: paraffin. The story of paraffin serves as a cautionary tale on the importance of long-term safety studies prior to the approval of new therapies to the public. Witness the evolution history of the field of aesthetic medicine through the extraordinary historical cosmetic filler before and after images. #DermalFillers #Fillers #CosmeticInjections 00:00 - Introduction 01:11 - Origin of dermal fillers in the late 1800's 01:39 - First surgical implant materials, gold, ivory, etc. 01:55 - Invention of hypodermic needle 02:13 - First use of fat transplantation in medicine 02:32 - First injection of fat via hypodermic needle (please note video actually shows a photo of Dr. Erich Lexer rather than Dr. Eugen Hollander) 03:16 - Discovery of Paraffin 03:39 - Invention of Vaseline 04:06 - First injection of paraffin injections in medicine 04:18 - First use of paraffin injections in plastic surgery 04:45 - Filler before and after results from 100 years ago with paraffin 06:09 - Dermal filler injection complications, early: including vascular embolization of filler, vision loss, stroke, pulmonary embolism 07:24 - Dermal filler injection complications, late: granulomas, paraffinomas, photos of filler complications from 100 years ago.