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A talk on the association between smoking cessation and mental health by Gemma Taylor, Doctoral Researcher in Public Health, Epidemiology and Biostatistics at the University of Birmingham. Introduction: Smoking is a major risk factor for development of serious disease and smoking cessation greatly reduces this risk. The association between smoking, smoking cessation and mental health however, is less clear-cut, therefore we aimed to further investigate this association. Methods: The first study was a systematic review and meta-analysis of longitudinal studies to determine the difference in change in mental health between quitters and continuing smokers. The second study was a prospective analyses of individual level-patient data from five trials for smoking reduction treatment, in which the association between cessation and change in mental health was explored using propensity score matching (PSM). Results and interpretations: Smoking cessation was associated with reduced depression, anxiety, and stress and improved positive mood and quality of life compared with continuing to smoke. The effect size seems as large for those with psychiatric disorders as those without. The effect sizes were equal or larger than those of antidepressant treatment for mood and anxiety disorders. PSM analyses showed that most of the association between cessation and improved mental health appears not to be explained by confounding or group membership bias.