Journal Club #23: Kratom Alkaloids Studied in Combination with Chemotherapy скачать в хорошем качестве

Journal Club #23: Kratom Alkaloids Studied in Combination with Chemotherapy

Disclaimer: None of the content on this podcast or on KratomScience.com constitutes medical advice, nor is it intended to be the wink wink kind of medical advice. Go to a doctor if you’re sick. Do not refuse treatments that have been shown to be beneficial from years of hard work by scientists in the medical field. We’re all adults here and we know that there’s no evidence kratom is a cure for any disease, virus, infection, or any ailment. Today Dr. Jon and Brian look at a study from University of Science in Malaysia, testing whether kratom alkaloids can be “chemosensitizers”, in other words, help chemotherapy drugs in killing or slowing the proliferation of cancer cells. In this in vitro study on cancer cell lines, researchers found that a combination of the kratom alkaloids mitragynine and speciociliatine helped the chemo drug cisplatin in slowing and killing throat cancer cells. The research also showed that any combination of kratom alkaloids does NOT slow or kill cancer cells on its own. Plus, Dr. Jon talks about the latest on cancer and cannabis/cannabinoids. We end with talking about the HHS comment period and potential international controls on kratom in the future. Study referenced in this podcast: Domnic, G., Jeng-Yeou Chear, N., Abdul Rahman, S. F., Ramanathan, S., Lo, K. W., Singh, D., & Mohana-Kumaran, N. (2021). Combinations of indole based alkaloids from Mitragyna speciosa (Kratom) and cisplatin inhibit cell proliferation and migration of nasopharyngeal carcinoma cell lines. Journal of ethnopharmacology, 279, 114391. Advance online publication. https://doi.org/10.1016/j.jep.2021.11... Follow Dr. Jonathan Cachat on Social Media @jcachat Music: Captain Bigwheel, “Moonrunner” Kratom Science Journal club is produced by Brian Gallagher for KratomScience.com