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The liver is relatively immunotolerant due to exposure to foreign antigens through portal circulation, but most liver diseases nonetheless result from failure to resolve inflammation once it is triggered. Several pathogens can infect the liver, but the liver is particularly vulnerable to the hepatitis viruses, A, B, C, D, and E, which preferentially replicate within hepatocytes and which have evolved mechanisms to modulate the immune response to favor viral replication. While each of these can cause acute hepatitis, HBV and HCV can cause chronic hepatitis. HCV can be successfully treated with direct-acting antiviral agents, but HBV can become re-activated after treatment due to the presence of cccDNA in the nucleus. 00:00 Introduction 00:26 Acute hepatitis 02:01 Chronic hepatitis 02:51 Hepatitis C virus 04:08 Hepatitis B virus 06:09 Summary Disclaimer: This video has been made available without warranty for informational and educational purposes only and is not intended to substitute for the advice of a medical professional.