The Benefits of the Proopiomelanocortin (POMC) gene скачать в хорошем качестве

The Benefits of the Proopiomelanocortin (POMC) gene

The POMC gene plays a vital role in encoding the proopiomelanocortin protein, which is subsequently cleaved into several physiologically significant peptides that exert their effects throughout the body via binding to melanocortin receptors One such peptide, adrenocorticotropic hormone (ACTH), binds to the melanocortin 2 receptor (MC2R) & stimulates the release of the hormone cortisol, which is acrucial regulator of glucose homeostasis, the stress response & anti-inflammatory processes The melanocyte stimulating hormones (α-MSH, β-MSH, γ-MSH) derive from POMC as well. α-MSH binds melanocortin 1 receptor (MC1R) on melanocytes, inducing melanin production & regulating pigmentation of skin & hair β-MSH interacts with melanocortin 4 receptor (MC4R), predominantly in the brain, to modulate energy homeostasis and bodyweight. α-MSH can also bind MC4R to contribute to this energy balance regulation γ-MSH appears to bind melanocortin 3 receptor (MC3R) & participate in sodium homeostasis and blood pressure control Finally, the POMC-derived β-endorphin peptide binds opioid receptors in the central nervous system, activating analgesic & euphoric signaling pathways From a decentralized medicine perspective, understanding how this single POMC gene locally encodes protein precursors that disperse systemically to regulate pivotal physiological processes via receptor binding elegantly demonstrates the biological principles of subsidiarity and interdependence Advancing knowledge of POMC could improve personalized prevention & treatment strategies for disorders of pigmentation, energy metabolism, pain, & cardiovascular health