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#cPass™ is a novel test that measures neutralising antibodies against #SARS-CoV-2, the virus that causes Coronavirus Disease 2019 (#COVID19). Not all antibodies produced against SARS-CoV-2 are equal as only neutralising antibodies can prevent SARS-CoV-2 from infecting a cell. cPass™ is based on the surrogate virus neutralisation test (sVNT) developed at Duke-NUS Medical School. Unlike conventional assays that detect neutralising antibodies, cPass™ uses engineered proteins to mimic the virus-host interaction, and thus does away with the need for live SARS-CoV-2 virus and biosafety level (BSL) 3 containment. This video is a guide on how to use the cPass™ test kit. It is not meant to replace the Instruction Manual. Please adhere to all safety guidelines in place at your institution. Should you have any queries about the use of cPass™, please contact the manufacturer. Their contact information can be found on the Instruction Manual. cPass™ is a collaboration between : Duke-NUS Medical School - https://www.duke-nus.edu.sg/ DxD Hub - https://www.a-star.edu.sg/accelerate/... Genscript - https://www.genscript.com/ You can read about the science behind cPass™ here: https://rdcu.be/cbNRe Tan, C.W., Chia, W.N., Qin, X. et al. A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction. Nat Biotechnol 38, 1073–1078 (2020). In November 2020, cPass™ was granted Emergency Use Authorisation (EUA) by the US Food and Drug Administration. More information here: https://www.fda.gov/news-events/press... Video was revised on 5 March 2021.