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Watch the Full Video at https://www.jove.com/v/50865/primary-.... Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation - a 2 minute Preview of the Experimental Protocol J. Geraldo Valadez, Anuraag Sarangi, Christopher J. Lundberg, Michael K. Cooper Vanderbilt University Medical Center, Department of Neurology; Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center; Veteran Affairs TVHS, Neurology Service; Malignant gliomas constitute a heterogeneous group of highly infiltrative glial neoplasms with distinct clinical and molecular features. Primary orthotopic xenografts recapitulate the histopathological and molecular features of malignant glioma subtypes in preclinical animal models. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments