Ep 28 - ⚕️ Development of Tapinarof & Treatment of Psoriasis | The Future of Dermatology Podcast скачать в хорошем качестве

Ep 28 - ⚕️ Development of Tapinarof & Treatment of Psoriasis | The Future of Dermatology Podcast

🔔 👉 SUBSCRIBE to The Future of Dermatology Podcast to stay up-to-date on our latest episodes. Summary In this episode of the Future of Dermatology podcast, Dr. Fara Kamangar and Dr. Tina Bhutani discuss the mechanism of action of aryl hydrocarbon receptors (AHR) and its potential in dermatology. They explore the history of AHR and its connection to coal tar, as well as its role in inflammation, antioxidant activity, and metabolism. They also touch on the importance of considering the impact of circadian rhythms and sleep on skin health. The conversation highlights the potential of AHR-targeted therapies in achieving longer remissions and the need to view psoriasis patients as a whole, addressing comorbidities and environmental factors. The episode concludes with a discussion on the future of dermatology, including the possibility of directly targeting resident memory T cells and the further exploration of AHR mechanisms. This episode is sponsored by an educational grant from the company Dermavant. Takeaways -Aryl hydrocarbon receptors (AHR) have a complex mechanism of action and can have anti-inflammatory, antioxidant, and metabolic effects. -AHR-targeted therapies, such as tofacitinib, have shown promise in achieving longer remissions in psoriasis patients. -Considering the impact of circadian rhythms and sleep on skin health is important, as sleep loss can increase inflammation and affect skin diseases. -Psoriasis patients should be viewed as a whole, addressing comorbidities and environmental factors. -The future of dermatology may involve directly targeting resident memory T cells and further exploring the mechanisms of AHR. -AHR-targeted therapies may offer new possibilities for treating inflammatory skin diseases and achieving longer remissions. Chapters 00:00 Introduction 02:24 Understanding the Mechanism of Action of Aryl Hydrocarbon Receptors 09:07 The Impact of Circadian Rhythms and Sleep on Skin Health 12:43 Viewing Psoriasis Patients as a Whole 16:39 The Potential of AHR-Targeted Therapies in Achieving Longer Remissions 22:35 Exploring the Mechanisms of Aryl Hydrocarbon Receptors 🎧 Prefer to listen? Find us on Podbean! https://thefutureofdermatology.podbea... ✍️ Drop us a comment below and let us know what types of dermatology questions you might have that you're too embarrassed to ask your dermatologist.