Hyperinsulinism in Children: Paige's Story скачать в хорошем качестве

Hyperinsulinism in Children: Paige's Story

For decades, Children’s Hospital of Philadelphia has been on the forefront of treating hyperinsulinism. http://www.chop.edu/hyperinsulinism See how that expertise benefited Paige, who was cured. Paige’s family initially sought treatment at another hospital, but Paige’s blood sugar wouldn’t stay in the safe range. Her parents brought her to CHOP. There, Surgeon-in-Chief N. Scott Adzick was able to remove only the part of her pancreas that was making too much insulin, preserving the rest. Dr. Adzick has performed more pancreatectomies than any other surgeon — more than 500 — and Paige was cured of the disease. Dr. Adzick is part of the multidisciplinary team that makes up CHOP’s Congenital Hyperinsulinism Center, the most active center in the world. HI is rare, with only one case in 50,000 births, but CHOP’s unparalleled experience treating these children means patients receive the best, most advanced care available. The center is directed by pediatric endocrinologist Diva De Leon, MD. Further testing determined that Paige had an uncommon type of HI called localized islet nuclear enlargement or LINE. LINE-type occurs in about one in 500,000 births — making her case the rarest of the rare. When a baby has HI, the beta cells in their pancreas release way too much insulin, which lowers their blood sugar to dangerous levels. Severe low blood sugar can cause seizures and, potentially, brain damage, so it’s essential to raise sugar levels to the normal range, and keep them there. Sugar is also necessary for brain growth and development. Unfortunately, not all children can be cured. About half of the approximately 80 patients who come to CHOP each year can have their HI managed with medication. Other patients, who have a form of the disease called diffuse hyperinsulinism, need to have nearly all of their pancreas removed to keep their blood sugars under control. Researchers at Children’s Hospital are actively exploring ways to improve treatment for these children. Other children have a form of the disease called focal hyperinsulinism. This can often be cured through surgery.