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Very often I see vimentin immunohistochemical stain ordered on spindle cell tumors by other pathologists. This video explains the proper use and interpretation of vimentin in soft tissue pathology (just kidding...there is no proper use!). I never order vimentin, and I've never once seen it change the diagnosis in a case. Outside of soft tissue pathology, there may be some role for vimentin that I'm not aware of. But for spindle cell tumors, it's basically rubbish. A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology). Video created by Jerad Gardner, MD, in 2010 (after seeing one too many vimentin stains ordered by others!). I originally posted it on an old YouTube channel but moved it here when I found out that many people were unaware that I was the one who made the video. Video is intended to be funny and tongue in cheek but also to make an important point: STOP ordering vimentin!!! Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation. Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos. Follow me on: Snapchat: JMGardnerMD Twitter: @JMGardnerMD Instagram: @JMGardnerMD Kiko: https://kikoxp.com/jerad_gardner1 Facebook: / jmgardnermd