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Lecture by Professor Robert Langer, Massachusetts Institute of Technology, at the Molecular Frontiers Symposium "Frontiers of New Knowledge in Science" in Hong Kong, Nov 15-17, 2024. ABSTRACT Advanced chemical delivery systems are having an enormous impact on human health. We start by discussing our early research on developing the first controlled release systems for macromolecules and the isolation of angiogenesis inhibitors and how these led to numerous new therapies. This early research then led to new drug delivery technologies including chemical nanoparticles and nanotechnology that are now being Used for treating cancer, other illnesses and in vaccine delivery including COVID vaccines. In addition, by combining mammalian cells, including stem cells, with synthetic polymers, new approaches for engineering tissues are being developed that may someday help in various diseases. Examples in the areas of cartilage, skin, blood vessels ,and heart tissue are discussed.