Tip-75;Inflammatory myofibroblastic tumor of the mesentery скачать в хорошем качестве

Tip-75;Inflammatory myofibroblastic tumor of the mesentery

Tip-75; Inflammatory myofibroblastic tumor (IMT) is a distinctive fibroblastic/myofibroblastic neoplasm of intermediate biological potential. It has a wide age range and occurs in a variety of locations in the GIT including the mesentery. It usually presents in relation to an abdominal mass effect but might be associated with systemic symptoms. It is believed that this tumor derives from myofibroblastic cells, although it may represent a proliferative lesion of fibroblastic reticulum cells. Microscopically, IMT is cellular, with fascicular growth of plump spindle cells exhibiting vesicular chromatin and eosinophilic cytoplasm, with inflammatory cells, predominantly plasma cells and lymphocytes. The background shows sometimes fibrosis/ sclerosis and occasionally myxoid changes. Pleomorphism is moderate, and mitosis is infrequent. Fibrosis and calcification can be seen in the stroma. ALK-immunostain is reported in up to 60% of cases, and more recently ROS-1 immunostain is reported in a subset of cases.