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Gastritis This video gives you a comprehensive account on gastritis, if you are preparing for your final year exams or semester exams this might help you to touch gastritis to the point. Treatments will be discussed in another video. In simple terms, gastritis occurs when the lining of the stomach becomes inflamed after it's been damaged. Here the word “inflamed” should be defined a bit. Inflammation is the body’s immune system’s response to an irritant. These irritants may be Pathogens (germs) like bacteria, viruses or fungi, External injuries like scrapes or damage through foreign objects, Effects of chemicals or radiation. It's a common condition with a wide range of causes. For most people, gastritis is not serious and improves quickly if treated. But if not, it can last for years. Often due to imbalance of luminal acidity and mucosal defense that discussed above, predispose the gastric mucosa to acid induced injury and inflammation. This is called as gastritis. If the exposure to the causative factors is short lived gastritis is named as acute gastritis and if there is persistent exposure to the causative factors it is called as chronic gastritis. In acute gastritis, mucosa is Hyperemic, congested and edematous. Minimal inflammatory cells can be seen histologically and quickly heals by resolution, once the injurious agent is removed. Causes predisposing acute gastritis include NSAID and Aspirin (due to inhibition of PG synthesis), Alcohol, Acid and alkali ingestion (due to direct injurious effect on the gastric epithelial cells), Severe physiological stress like sepsis, multiple trauma, burns, intracranial lesions. Common symptoms due to gastritis include epigastric pain and discomfort, nausea and vomiting. These symptoms are called dyspeptic symptoms. In acute gastritis symptoms are more severe and in chronic gastritis less severe but persistent. If there are erosions and ulcers there can be hematemesis and melena. Complications of acute gastritis include Erosions and ulcers leading to bleed. Sometimes bleeding can be profuse and require blood transfusion to prevent hypovoleamic shock. Ulcers can penetrate the full thickness of the wall and cause perforations giving rise to peritonitis and internal bleeding. Diagnosis, Upper GI endoscopy, Upper GI endoscopy is a procedure which uses an endoscope—a flexible tube with a camera—to see the lining of upper GI tract, including esophagus, stomach, and duodenum. During upper GI endoscopy, biopsies are obtained by passing an instrument through the endoscope to take small pieces of tissue from stomach lining. Stool tests, Stools are checked for H. pylori infection and for blood in stool, a sign of bleeding in stomach. Urea breath test, urea breath test is used to check for H. pylori infection. For the test, patient swallow a capsule, liquid, or pudding that contains urea that is “labeled” with a special carbon atom. If H. pylori is present, the bacteria will convert the urea into carbon dioxide. After a few minutes, patient will breathe into a container, exhaling carbon dioxide. If the test detects the labeled carbon atoms, it confirm an H. pylori infection in digestive tract. #Gastritis#acutegastritis#chronicgastritis#Symptoms#Diagnosis