Pichia pastoris: the microbial protein expression platform you’re probably underestimating скачать в хорошем качестве

Pichia pastoris: the microbial protein expression platform you’re probably underestimating

Today we’re diving into the world of expression systems with Iskander Dib, of Validogen (https://www.validogen.com) and we’ll explore the remarkable potential of Pichia pastoris, a methylotrophic yeast that’s revolutionizing pharmaceutical protein production and beyond.  From industrial enzymes to biomaterials, food, feed, and diagnostics, Pichia offers a reliable, scalable, and cost-efficient platform for recombinant protein expression.  Iskander explains how biotechs can unlock Pichia’s full potential through Validogen’s sophisticated tools and strategies, fine-tuning protein expression with innovative genetic approaches and robust screening systems to deliver unmatched yields and quality.  01:06               Why pichia is often overlooked or underestimated 03:29               The basics of pichia pastoris 05:25               How pichia compares to microbial hosts like E.coli 08:14               Key advantages over mammalian cell systems 10:21               Pichia as a system for secreted production 11:30               Pichia and post-translational modifications 14:30               The challenges of working with pichia 16:25               Strain optimization and genetic engineering 17:29               Meet Iskander Dib and Validogen 19:03               The UNLOCK PICHIA platform 24:00               Real-world applications of pichia pastoris in biopharma 27:19               When pichia outperforms expectations 28:25               Adapting pichia for emerging fields 30:23               Advice for those considering pichia pastoris for protein expression 33:23               Learn more about Validogen This episode is sponsored by Validogen (https://www.validogen.com) . @Validogen Interested in being a sponsor of an episode of our podcast? Discover how you can get involved here! (https://www.labiotech.eu/advertise/?u...)   Stay updated by subscribing to our newsletter (https://www.labiotech.eu/newsletter/?...) To dive deeper into the topic:  • Case Study: methanol-free bivalent VHH production in pichia (https://www.validogen.com/fileadmin/c...) • Unlocking pichia for industry (https://www.validogen.com/fileadmin/c...)