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Developmental and Epileptic Encephalopathies

Armando Anido, Chief Executive Officer at Zynerba Pharmaceuticals discusses Developmental and Epileptic Encephalopathies (DEEs) and his company's focus on these rare epilepsy syndromes. DEEs are a heterogeneous group of rare and ultra-rare epilepsy syndromes that manifest with seizures, behavioral disturbances, or EEG abnormalities that can directly worsen cognition and behavior. These disorders are often progressive and are highly resistant to treatment. These syndromes involve: Impaired development (developmental encephalopathies) Regression of developmental progress (epileptic encephalopathies) Examples of DEEs include early myoclonic encephalopathy, epileptic encephalopathy with continuous spike and wave during sleep, and certain syndromes including Ohtahara, West, Landau-Kleffner, Lennox-Gastaut, Doose and Dravet. Treatment of seizures or EEG abnormalities is expected to improve the cognitive or behavioral deficits and reduce the seizures.