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A healthy heart has four chambers: two atria and two ventricles. However, some babies are born with a misshapen heart. These babies have one normal ventricle and one small or malformed ventricle. Often, they also have a hole between the left and right sides of the heart, allowing deoxygenated blood and oxygenated blood to mix. Fortunately, these kinds of defects — known as single-ventricle defects or SVDs — are rare. Babies born with an SVD can be treated through a sequence of surgeries, as shown in this animation. Surgeons are also developing a pioneering technique to start treatment from within the womb, in the hope of saving even more lives. Read more in https://nature.com/collections/heart-... This Nature Video is editorially independent. It is produced with third party financial support. Read more about Supported Content here: https://partnerships.nature.com/comme... Sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday: https://go.nature.com/371OcVF