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Tuberculosis still poses a serious problem around the world with labs around the world such as the Ramakrishnan lab in the University of Cambridge working to eradicate the disease. Dr Shanahan is particularly interested in two virulence factors that are essential for the bacteria to cause disease. His work has focused on understanding why and how these proteins are used to successfully establish infection and he talks about his work towards eradicating the disease. Jonathan Shanahan is a postdoctoral medical research associate at Cambridge University affiliated with the Ramakrishnan Research Group. He has dedicated his work to the mycobacterium ESX-1 and advanced therapies for tuberculosis (TB) by leading his field's understanding of ESX-1-mediated virulence in early phases of infection. Jonathan continues to work on TB with interests in macrophage phagosomal damage, granuloma formation, and virulence. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx