UCL AI in Medicine Manolis Kellis (February 3, 2021) скачать в хорошем качестве

UCL AI in Medicine Manolis Kellis (February 3, 2021)

0:00 Introduction and Start 1:47 The Promise of Genetics 4:37 The Challenge of Mechanism 9:25 Disease mechanism dissection methodology 11:23 Epigenome importance and introduction 15:33 Non-coding circuitry example 17:44 FTO, Obesity, and Thermogenesis 21:15 Manipulate circuitry TO reverse disease phenotypes 27:53 Reference Epigenomes to predict disease-relevant tissues 33:33 Immune basis of Alzheimer's Disease 36:12 EpiMap expansion to 833 Epigenomes 42:48 Genetic + Epigenetic + Transcriptional Variation 51:07 Single-cell dissection of Alzheimer's 56:58 Single-cell dissection of Schizophrenia 1:02:46 ALS, Fronto-Temporal Dementia, Huntington's 1:03:28 Multi-Region, Sub-Region, Spatial Transcriptomics 1:09:19 Microglia, scATAC, Somatic mutation mosaicism 1:14:42 Bulk + single-cell integration: Cell-type-specific eQTLs 1:17:21 Multi-phenotype dissease dissection and EHRs 1:20:30 Multi-tissue convergence in obesity, cancer, aging 1:27:07 High-throughput dissection of disease 1:30:50 Summary, Acknowledgements, and open Positions 1:33:00 Q1: Personalized vs Precision Medicine 1:34:44 Q2: Path from Targets to Treatments 1:35:44 Q3: Dangers of Genomic Interventions 1:39:17 Q4: Treatments for Obesity 1:41:08 Q5: Overeating and Food Inequalities 1:43:30 Q6: Extending Productive Human Lifespan 1:45:17 Q7: Lex Fridman conversations 1:45:45 Q8: Genetics, environment, and behavior in disease 1:49:39 Q9: Importance of diversity 1:51:30 Q10: Already answered 1:51:49 Q11: Multiple Sclerosis, Alzheimers, and inflammatory response 1:55:21 Q12: Transhumanism, Psychiatry, and Child Behavior 1:57:56 Q13: Obesity, Willpower, Genetics, Environment, Behavior 2:00:02 Q14: Patents co-ownership of methods, tools, mechanisms 2:01:10 Q15: mRNA treatment duration and reversal 2:02:39 Q16: ML for drug development 2:03:40 Q17: Genetics and Insurance Companies 2:06:10 Q18: Metabolism and Reactive Oxygen Species 2:06:44 Q19: Reversing Thermogenesis and World Hunger 2:09:31 Q20: Favorite Podcasts 2:09:38 Q21: Thanks 2:09:44 Q22: Delivery technologies, Moderna, BioNTech/Pfizer 2:10:50 Q23: Favorite Books 2:12:07 Q24: Feels like a podcast 2:12:27 Q25: Funding for Science 2:13:22 Goodbye and Wrapping up