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This video Presentation was recorded at the Brain Tumour National Conference in Toronto, Ontario on Saturday, October 20th, 2018 with Sabra Salim and Nikoo Aghaei (McMaster University) for part of The Pam and Rolando Del Maestro Family Undergraduate Student Research Competition. Hypothesis: We hypothesize that cells harboring IDH1-mt status have increased tumorigenic, proliferative, self renewal and malignant transformation capacity. When used in combination with current treatment options, IDH1 inhibitors may provide a novel therapeutic modality and drive preventative treatment options for high-grade glioma transition for patients with diffuse astrocytoma. Furthermore, we hypothesize that induction of a high-grade phenotype may elucidate novel cell signalling pathways and subsequent targeting of markers in malignant transformation. Learn more about the National Conference: www.braintumour.ca/braintumourconference. Connect with Brain Tumour Foundation of Canada: Facebook: / braintumourfdn Twitter: / braintumourfdn Instagram: / braintumour. . Pinterest: / braintumourfdn Call Toll Free 1-800-265-5106 or locally 519-642-7755 - call with any questions and connect today! Brain Tumour Foundation of Canada 205 Horton St E, Suite 203, London, ON N6B 1K7 http://www.BrainTumour.ca Charitable Registration #BN118816339RR0001 Copyright and Terms of Use Statement - Videos Copyright of all videos created by Brain Tumour Foundation of Canada on this website, including the underlying HTML, text, illustrations, designs, icons, audio clips, video clips, documents, products, software and all other content is either owned by the Brain Tumour Foundation of Canada, or Brain Tumour Foundation of Canada has obtained a license to use the materials. The videos on the site are protected by the Copyright Act. None of the videos may be copied, reproduced, distributed, republished, downloaded, or transmitted in any form or by any means, without the prior written consent of Brain Tumour Foundation of Canada, or the original creator, where applicable. All information within the videos has been posted to provide Canadians affected by a brain tumour with support, education, information and an understanding of research programs or to thank donors and supporters for their contributions. The information has been posted with the intent that it be readily available for personal and public non-commercial (educational) use. The allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research.