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THT 2025: GSN Ablation in HFpEF

THT Conference 2025 - Findings show catheter ablation of the right greater splanchnic nerve (GSN) in patients with heart failure with preserved ejection fraction (HFpEF) reduces estimated stressed blood volume ... Dr Marat Fudim (Duke University, Durham, US) joins us to discuss findings supporting the REBALANCE-HF trial (NCT04592445), investigating the safety and effectiveness of GSN ablation using the Axon System (Axon Therapies, Inc.) in patients with HFpEF. The primary outcome measures were change in mean PCWP at 1 month follow up and evaluation of device or procedure-related serious adverse events at 1 month follow up. REBALANCE-HF trial: patients with FHpEF randomized to splanchnic right greater nerve ablation with intent to treat and reduce amount of volume shifted from splanchnic compartment of abdominal cavity into chest which is a driver of cardiac decompensation in HFpEF and HFrEF. Larges, randomized, feasibility study for HFpEF with device-based research. Who benefits from mechanism of reducing stressed blood volume. This analysis: looking at stressed blood volume - shifting of blood from periphery to central compartment of heart and lungs - splanchnic right greater nerve ablation tries to decrease blood shifting. Using sub-pop of patients from REBALANCE-HF who did respond from reducing stressed blood volume calculated invasively obtained hemodynamiscs through rest and excersize - Interview Questions: 1. What is the reasoning behind the trial? 2. What is the current research landscape for GSN ablation in HF patients? 3. What was the patient population, and what were the key findings? 4. What are your take-home messages? 5. What further research is needed? Recorded remotely from Durham, US, 2025 Editors: Yazmin Sadik, Jordan Rance Videographers: David Ben-Harosh Support: This is an independent interview produced by Radcliffe Cardiology. Visit Radcliffe Cardiology: https://www.radcliffecardiology.com/ This content is intended for healthcare professionals only. Radcliffe brings medical knowledge, insight and innovation to life for CV clinicians around the world, using our communications & creative expertise, our platforms and connections across the community to help transform theory into practice faster. Like us on Facebook:   / radcliffecardiology   Follow us on X: https://x.com/radcliffeCARDIO