3 Wild Plants That Replace Your Entire Medicine Cabinet — Why Were They Reclassified? скачать в хорошем качестве

3 Wild Plants That Replace Your Entire Medicine Cabinet — Why Were They Reclassified?

Three wild plants once found in every grandmother's medicine kit faced three completely different regulatory fates. Artemisia annua, a weedy herb used in Chinese medicine for over two thousand years, was transformed into the Nobel Prize-winning antimalarial drug artemisinin after Tu Youyou decoded an ancient cold-extraction method during a secret military project. It now saves an estimated six hundred thousand lives annually, yet the WHO actively discourages using the raw plant as tea. Ephedra sinica, prescribed safely by traditional healers for millennia, became a billion-dollar supplement industry disaster in the 1990s when concentrated doses caused heart attacks, strokes, and deaths in otherwise healthy people, leading to a full FDA ban in 2004. The plant never changed — the dosage and profit motive did. White willow bark, humanity's original painkiller dating back thirty-five hundred years, inspired the creation of aspirin before being dismissed as a crude folk remedy. Then clinical studies in the early 2000s proved it works through its own distinct mechanism, earning formal reclassification as an approved herbal medicine by the European Medicines Agency. This video explores how the line between medicine and weed is thinner than we think, shaped not just by science but by money, politics, and timing. 📚 SOURCES: Tu Youyou, Artemisinin -- A Gift from Traditional Chinese Medicine to the World (Nobel Lecture), Angewandte Chemie International Edition, 2016 Miller LH and Su X, Artemisinin: Discovery from the Chinese herbal garden, Cell, 2011 Haller CA and Benowitz NL, Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids, New England Journal of Medicine, 2000 Bent S et al., The relative safety of ephedra compared with other herbal products, Annals of Internal Medicine, 2003 Shekelle PG et al., Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis, JAMA, 2003 Abourashed EA et al., Ephedra in perspective -- a current review, Phytotherapy Research, 2003 Wolfe S, Ephedra -- scientific evidence versus money/politics, Science, 2003 Vlachojannis JE et al., A systematic review on the effectiveness of willow bark for musculoskeletal pain, Phytotherapy Research, 2009 Schmid G and Hofheinz W, Total synthesis of qinghaosu, Journal of the American Chemical Society, 1983 Chrubasik S et al., Treatment of low back pain exacerbations with willow bark extract: a randomized double-blind study, American Journal of Medicine, 2000 European Medicines Agency Committee on Herbal Medicinal Products, Assessment report on Salix cortex and related preparations, EMA, 2017 van der Kooy F and Sullivan SE, The complexity of medicinal plants: the traditional Artemisia annua formulation current status and future perspectives, Journal of Ethnopharmacology, 2013 Wang J et al., Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nature Communications, 2015 Fairhurst RM et al., Artemisinin-resistant malaria: research challenges opportunities and public health implications, American Journal of Tropical Medicine and Hygiene, 2012 MacLagan TJ, The treatment of acute rheumatism by salicin, The Lancet, 1876 Stone E, An account of the success of the bark of the willow in the cure of agues, Philosophical Transactions of the Royal Society, 1763 Nagai N, Ephedrin, Pharmaceutical Zeitung, 1887 Cumming JN et al., Antimalarial activity of artemisinin (Qinghaosu) and related trioxanes: mechanism(s) of action, Advances in Pharmacology, 1996