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Gary Cutter, MS, PhD, UAB School of Public Health, Birmingham, AL, discusses the phenomenon of pseudo-atrophy when using brain volume measured by MRI as an outcome measure in multiple sclerosis (MS) clinical trials. Prof. Cutter notes that pseudo-atrophy is more highly correlated with inflammation and relapses than with progression, and highlights that brain atrophy changes very slowly and may not be a useful outcome measure in short-term studies. This interview is part of our coverage of the 11th Annual Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum, held in San Diego, CA. These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.