Studying evolution to banish aging - a new frontier in gerontological drug development скачать в хорошем качестве

Studying evolution to banish aging - a new frontier in gerontological drug development

"I would say that individuals born in the second half of the 21 century could live for centuries in quite good health." Professor Michael Rose. Discover the scientific theory behind his hypothesis here. The interview: Ira Pastor, ideaXme Longevity and Aging ambassador and founder of Bioquark interviews Michael Rose, Distinguished Professor, Ecology and Evolutionary Biology University of California, Irvine and Founder and Chief Scientist Lyceum. Ira Comments: In this ideaXme episode, as we continue our journey through the biological architecture of the ageing process, we are going to take an important trip down to the level of the genome But not to the traditional simplified / static / reductionist genome that the majority of the public is treated to. We will talk about a complex genome – one that takes into account that the genome is fluid and highly networked; filled with endless feedback loops and hierarchies of control; where intricate phenomena exist including epistasis, pleiotropy, and alternative splicing; and a genome which is continually interacting with its environment (including the metabolic architecture of the cell, other cells, individuals, species) yielding variations in traits. Dr. Michael Rose is one of the world’s leading scientists in aging, biological immortality, and human evolution. For the last 40 years his main area of work has been studying biological ageing via the technique of experimental evolution. He is one of the pre-eminent thinkers behind such complex theories as “the declining forces of natural selection”, antagonistic pleiotropy and mortality-rate plateaus. He is author of hundreds of research papers, and many books including: Evolutionary Biology of Aging Does Aging Stop? Methuselah Flies: A Case Study in the Evolution of Aging, The Long Tomorrow: How Advances in Evolutionary Biology Can Help Us Postpone Aging Darwin's Spectre. As well as a wonderful synthesis of his work at www.55theses.org, he distils down a lifetime of knowledge in a very readable format. On this ideaXme show we will explore: Dr. Rose’s background, how he became interested in science, evolutionary biology, and aging. His experience conducting the longest-running longevity experimental evolution / breeding experiment in Fruit flies (Drosophila melanogaster) producing organisms with 4 times the normal life span, including the topline physiologic findings in terms of organismal fitness, fertility robustness, and resilience, as well as the core “omics” learnings (including genomic, proteomic, transcriptomic, and metabolomic): Scientific and actionable dietary and lifestyle interventions from his 55theses. A discussion about the future in terms of “Theses 56” and the development of new biomedical developments based on his knowledge base. All links to Professor Michael Rose's work will be here www.radioideaxme.com from 26 February 2019. Follow @IraSamuelPastor Find out more: www.bioquark.com ideaXme is a podcast ambassador and mentor programme. Our mission is to move the human story forward by shining a light on the big ideas that have the potential to shape our world. We support creators, future creators and inform and entertain the curious amongst the general public. Follow ideaXme on Twitter: @ideaxm on Instagram: @ideaxme