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This video reviews current evidence on the use of chloroquine and hydroxychloroquine in COVID-19, including the previous and upcoming trials and the media coverage of these medications. Sources mentioned in this video: Lab-based (in vitro) studies with chloroquine/hydroxychloroquine and SARS-CoV-2: 1. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. (Cell Research). Link: https://www.nature.com/articles/s4142... 2. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). (Clinical Infectious Diseases). Link: https://www.ncbi.nlm.nih.gov/pmc/arti... 3. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. (Cell Discovery). Link: https://www.ncbi.nlm.nih.gov/pmc/arti... Human (in vivo) studies with hydroxychloroquine in COVID-19: 1. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. (International Journal of Antimicrobial Agents). Link: https://www.sciencedirect.com/science... 2. A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19). (Journal of ZheJiang University (Medical Sciences)). Link: http://www.zjujournals.com/med/EN/10.... 3. Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial. (medRxiv). Link: https://www.medrxiv.org/content/10.11... National Institutes of Health Clinical Trial for hydroxychloroquine in COVID-19: https://www.nih.gov/news-events/news-... NOTE: Given that this is a new infection and there is a lot of influx of new data every day, some of the information in this video may become outdated based on how the new data changes our understanding of the infection. The information in this video is accurate to April 19, 2020.