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This Video accompanies the manuscript: PI-RADS Steering Committee: The PI-RADS Multiparametric MRI and MRI-directed Biopsy Pathway. Padhani AR, et al. Radiology 2019 [in press] Summary statement: The PI-RADS MRI directed biopsy pathway enables the delivery of key diagnostic benefits to men with suspected cancer according to their clinical priorities. Key Points: • High-quality Prostate Imaging Reporting and Data System (PI-RADS) compliant multiparametric MRI should be performed before prostate biopsy in most men suspected of having clinically significant disease, who are likely to be offered active treatments. • A safety net of monitoring must be in place for patients who decline immediate biopsy after low likelihood MRI findings, including clinical, laboratory assays and imaging as per local clinical practice and consistent with clinical goals for individual patients. The roles and responsibilities of the participants and the circumstances that should trigger reinvestigations should be clearly defined. • For men proceeding to biopsy after intermediate/high-likelihood MRI findings (ie, PI-RADS category 3 or greater), a combination of systematic and targeted biopsies should be performed in biopsy-naïve men; only targeted biopsies are needed for men at persistent suspicion after prior negative findings on systematic transrectal US guided biopsy.