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In this Assay Guidance Manual Webinar from Dec. 11, 2025, Dr. Peter Sorger discusses the new approaches his group has developed for highly multiplexed imaging of single cells in tissues and tumors, how the data are used to generate spatial profiles of tumor-intrinsic and tumor-immune states predictive of disease progression and therapeutic response, and how his group aims to implement some of these profiles as clinical tests in the immediate future. Peter Sorger, Ph.D. is the Otto Krayer Professor of Systems Biology at Harvard Medical School, founding head of the Harvard Program in Therapeutic Sciences (HiTS), director of its Laboratory of Systems Pharmacology (LSP), and a professor of systems biology at Harvard Medical School. As head of HiTS, Dr. Sorger leads a university-wide effort to advance the basic and translational science used to develop new medicines, including new approaches to measure and model precision clinical trials. He also directs the LSP, the primary research program in HiTS, which joins together faculty members from eight institutions in a multidisciplinary effort to develop and apply new concepts in drug discovery. Dr. Sorger was cofounder of Merrimack Pharmaceuticals and Glencoe Software and is an advisor to multiple public and private companies and research institutes in the United States, Europe, and Japan. For more information about the Assay Guidance Manual eBook, workshops and webinars, visit https://ncats.nih.gov/research/resear....