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Master the gross anatomy and pathology of Radical Prostatectomy for prostate cancer specimens in this in-depth educational video. Designed for medical students, pathology residents, and pathologist's assistants, this resource focuses on the dissection, orientation, and preparation of prostate gland specimens removed for prostate cancer. We cover key anatomical landmarks such as the seminal vesicles, prostate capsule, and surgical margins, highlighting how to identify tumor involvement and critical pathological findings. Learn proper grossing techniques to prepare specimens for histological examination and ensure accurate diagnostic results. We teach you how to have an organized approach to dissection and sampling. We then review prostate anatomy and pT staging for prostatic adenocarcinomas. This video is an essential guide for those pursuing careers in surgical pathology or anatomy education. Enhance your understanding of prostate cancer pathology and improve your specimen handling skills with this detailed walkthrough! Chapters 00:36 Introduction 02:01 Normal prostate anatomy 03:07 Prostate zones and regions 04:10 Painting strategies to delineate zones 05:20 Cutting and organizing the specimen for submission 07:20 Textural and colour differences in the prostate gland that may indicate prostate cancer 12:40 Taking perpendicular section of the apical margin 13:12 Taking quadrant sections 13:40 Whole mount sections of prostate 15:52 Mega-cassette for histology 17:44 Review – Prostate Anatomy 19:35 Review – Margin sampling methods 20:05 Extra-prostatic Extension 21:10 Grossing Pearls – Radical Prostatectomy 22:06 Histology of prostate acinar adenocarcinoma 22:37 Gleason scoring and grade grouping 22:52 pT staging of prostate adenocarcinoma #Pathology #GrossAnatomy #MedicalEducation #Histopathology #ProstateCancer #RadicalProstatectomy #SurgicalMargins #ProstatePathology #MedicalStudents #PathologyResidents #SurgicalPathology #prostategland