4: Cognitive Decline and Glycation with Dr. Paul Reynolds скачать в хорошем качестве

4: Cognitive Decline and Glycation with Dr. Paul Reynolds

In this foundational lecture for the College of Glycation, Dr. Paul Reynolds unpacks the role of glycation in driving cognitive decline, mental health disorders, and neurodegenerative diseases like Alzheimer’s and Parkinson’s. He explains how sugar-related damage—via advanced glycation end products (AGEs)—disrupts brain function, fuels inflammation, and accelerates aging. By weaving together compelling scientific evidence, clinical insights, and practical strategies, Dr. Reynolds highlights how glycation—and its close partner, insulin resistance—create a metabolic storm that harms memory, mood, and long-term brain health. This episode equips viewers with knowledge and tools to combat glycation through diet and lifestyle, with a special focus on the promise of ketogenic therapies. Topics Covered -What glycation is and how AGEs form in the body -How glycation affects the brain and contributes to Alzheimer’s, Parkinson’s, and dementia -The link between insulin resistance, blood sugar, and cognitive dysfunction -Why conventional diabetes medications fall short in protecting brain health -The neuroprotective potential of ketosis and low-AGE diets -Actionable steps to reduce glycation and support long-term cognitive function Timestamps: 00:01 – Intro 00:37 – Glycation & Cognitive Decline 01:12 – What is Glycation? 01:48 – AGEs & Inflammation 02:29 – Brain’s Sugar Burden 03:08 – Research Findings 03:50 – Human Studies 04:30 – Mental Health Links 05:10 – Alzheimer’s & Parkinson’s 05:48 – Lab & Human Evidence 06:26 – Insulin Resistance 07:05 – Glucose Toxicity 08:25 – “Type 3 Diabetes” 09:04 – Blood-Brain Barrier 09:42 – Medication Limitations 11:01 – Broader Brain Impact 11:40 – Diet vs Medication 12:17 – Ketosis for Brain 12:58 – Ketones & Insulin Resistance 13:37 – Ketogenic Research 14:18 – Anti-inflammatory Effects 14:57 – Alzheimer’s Clinical Results 15:34 – Take Control 16:13 – Action Steps 16:54 – Final Thoughts About Dr. Paul Reynolds Dr. Paul Reynolds is a Professor of Cell Biology and Physiology at Brigham Young University. Known for his engaging, research-informed teaching style, Dr. Reynolds makes complex biomedical topics approachable and relevant. Through the College of Glycation series, he empowers viewers to understand and prevent the silent processes that drive chronic disease and accelerated aging. For more science-backed insights on glycation, oxidative stress, and metabolic health, subscribe and continue learning with the College of Glycation series. Questions? Leave a comment below. #CollegeOfGlycation #DrPaulReynolds #CognitiveDecline #Glycation #AGEs #AlzheimersDisease #Parkinsons #BrainHealth #InsulinResistance #MentalHealth #KetogenicDiet #HealthyBrainAging #MetabolicHealth #Neurodegeneration #NutritionScience #LowCarb #KetoDiet #Healthspan #SciencePodcast #CellBiology #HealthyLiving #BloodSugar #AntiAging #HealthEducation