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In this video, a board-certified anesthesiologist and neuro-critical-care physician, Christopher Voss, MD, takes you on a journey through the latest neuroscience and emerging quantum theories to explore what flips consciousness on and off under anesthesia. You’ll learn about the brain’s hidden “default ascending arousal network,” how anesthetics disrupt global neural communication, and bold new research suggesting microtubules and myelin-generated biphotons may form a quantum “Wi-Fi” that synchronizes distant neurons Topic in Script Reference Direct Link 1 Quantum biphotons in myelin Liu, Z., Chen, Y.-C., & Ao, P. (2024). Entangled biphoton generation in the myelin sheath. Physical Review E, 110(2), 024402. https://doi.org/10.1103/PhysRevE.110.... 2 Global Neuronal Workspace Theory (GNWT) Dehaene, S., & Naccache, L. (2001). Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework. Cognition, 79(1–2), 1-37. https://doi.org/10.1016/S0010-0277(00... 3 Integrated Information Theory (IIT) Tononi, G. (2004). An information integration theory of consciousness. BMC Neuroscience, 5, 42. https://doi.org/10.1186/1471-2202-5-42 4 Propofol blocks sensory signal progression Tauber, J. M., Brincat, S. L., Stephen, E. P., Donoghue, J. A., Kozachkov, L., Brown, E. N., & Miller, E. K. (2024). Propofol-mediated unconsciousness disrupts progression of sensory signals through the cortical hierarchy. Journal of Cognitive Neuroscience, 36(2), 394-413. https://doi.org/10.1162/jocn_a_02081 5 Default Ascending Arousal Network (dAAN) Edlow, B. L., Kinney, H. C., & colleagues. (2024). Multimodal MRI reveals brainstem connections that sustain wakefulness in human consciousness. Science Translational Medicine, 16, eadj4303. https://doi.org/10.1126/scitranslmed.... 6 Microtubule stabilization & delayed anesthesia Khan, S., Huang, Y., Timuçin, D., et al. (2024). Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats. eNeuro, 11(8), ENEURO.0291-24.2024. https://doi.org/10.1523/ENEURO.0291-2... 7 Orch-OR review (quantum consciousness) Penrose, R., & Hameroff, S. R. (2014). Consciousness in the universe: A review of the Orch-OR theory. Physics of Life Reviews, 11(1), 39-78. https://doi.org/10.1016/j.plrev.2013.... 8 MDMA-assisted therapy Phase 3 (PTSD) Mitchell, J. M., Bogenschutz, M., Lilienstein, A., et al. (2021). MDMA-assisted therapy for severe PTSD: A randomized, double-blind, placebo-controlled Phase 3 study. Nature Medicine, 27(6), 1025-1033. https://doi.org/10.1038/s41591-021-01... 9 McGreevey S. (2011). “Eight weeks to a better brain.” Harvard Gazette (news article on mindfulness neuroplasticity). https://news.harvard.edu/gazette/stor...