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This source is an integrated review detailing the therapeutic effects of hyperbaric oxygen therapy (HBOT), which involves breathing 100% pure oxygen at pressures greater than normal atmospheric pressure inside a sealed chamber. The text explains that HBOT fundamentally works by dramatically increasing the concentration of dissolved oxygen in the plasma, subsequently elevating the oxygen pressure gradient to deliver more oxygen deeper into tissues. Historically tracing the use of hyperbaric treatment from the 17th century, the review outlines the core mechanisms of therapeutic action at a cellular level, such as correcting hypoxia, reducing oxidative stress, and promoting healing through angiogenesis and collagen production. Finally, the authors extensively list and describe the wide range of accepted clinical indications for HBOT, including carbon monoxide poisoning, decompression sickness, and various non-healing wounds, while also discussing the common side effects, complications, and contraindications of the procedure. Source: Therapeutic effects of hyperbaric oxygen - integrated review Sen S, Sen S. Therapeutic effects of hyperbaric oxygen: integrated review. Med Gas Res. 2021;11(1):30-33