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Cell Adhesions And Junctions

Explore Cell–Cell Adhesion and Junctions with Dr. Faiza Learn how cells stick, communicate, and stay organized. This session explains the extracellular matrix, cell adhesion molecules, and the three major junction families. See where tight, gap, adherens, and desmosomal junctions lie. Understand hemidesmosomes and focal adhesions that anchor cells to the basal lamina. Ideal for physiology, anatomy, and histology learners. 🔬 Key Topics Covered: Extracellular Matrix: Collagen for tensile strength, elastin for stretch, fibronectin for adhesion. Cell Adhesion Molecules: Integrins, cadherins, Ig-superfamily, and selectins. Tight Junctions (Zonula Occludens): Occludin, claudins, JAM; barrier, polarity, and endothelial seals. Gap Junctions: Connexons/connexins; rapid electrical and metabolic coupling. Adherens Junctions: Cadherins linked to actin; cell–cell anchoring and signaling. Desmosomes: Spot-like anchors with intermediate filaments; high tensile strength. Cell–Matrix Anchors: Hemidesmosomes (integrins + intermediate filaments) and focal adhesions (integrins + actin). Clinical Links: Barrier defects, blistering disorders, arrhythmias, developmental and metastatic pathways. 🎓 Learning Objectives: Differentiate ECM components and their roles. Identify major CAMs and the junction each supports. Locate tight, gap, adherens, and desmosomal junctions in epithelia. Explain hemidesmosomes and focal adhesions in tissue anchoring. Relate junction dysfunction to clinical problems. 📚 Learning Resources: Phone: +92 310 7990649 Email: [email protected] Website: https://www.medicoseacademics.com/ Facebook:   / medicoseacademics   Instagram:   / medicoseacademics   YouTube:    / @medicoseacademics   Dr. Faiza Assistant Professor of Physiology MBBS (AIMC, lahore, Best Graduate) FCPS (Physiology) CHPE (Certificate in Health Professional Education) DHPE (Diploma in Health Professional Education) DHPE (Masters in Health Professional Education) MBA (Masters of Business Administration) MPH (Masters of Public Health) LinkedIn:   / faizaikram   Tags: Cell Junctions, Tight Junctions, Gap Junctions, Adherens Junctions, Desmosomes, Hemidesmosomes, Focal Adhesions, Integrins, Cadherins, Selectins, Immunoglobulin Superfamily, Extracellular Matrix, Collagen, Elastin, Fibronectin, Epithelial Polarity, Blood-Brain Barrier, Mucosal Barrier, Cell Adhesion Molecules, Physiology Lecture