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"Vitamin C" Vitamin C and Cancer - Dr. Linus Pauling - How To Live Longer and Feel Better - Vitamin C Dr. Linus Pauling and Dr. Abram Hoffer Vitamin C, Vitamin B3 (Niacin) and Prevention and Treatment of Cancer - Linus Pauling's talk for a gathering of Nobel Prize Laureates in Lindau, Germany Dr. Linus Pauling (Nobel Prize in Chemistry) recommended people take 3,000 mg to 18,000 mg of Vitamin C per day in his books. Dr Abram Hoffer recommended people take 500 mg to 3000 mg per day of Vitamin B3 (Niacin) - especially for depression, alcoholism, addictions, schizophrenia, etc. After being awarded the 1954 Nobel Prize in Chemistry "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances", Linus Pauling turned his attention to a range of medical issues, including topics like the mechanisms of general anaesthesia or the molecular mechanisms of sickle cell anaemia, which he both discussed in his Lindau lecture. He also briefly worked on mental diseases. This brought him to the vitamins, some of which were evaluated as drug candidates for mental patients. What ensued was some of his probably most controversial work, which culminated in the claim that vitamin C megadoses (around 10 g per day) would be suited to treat cancer and support health in general. Pauling himself took at least 10 g of vitamin C per day for more than 20 years. Pauling clearly outlines the rationale that led him to support vitamin C megadoses. He begins by pointing out the importance of vitamin C for collagen biosynthesis (collagen is a structural protein responsible for the integrity of skin, hair, muscles, tendons and other tissues) and hypothesizes that vitamin C could inhibit the metastasis of cancer by generally strengthening tissues due to improved collagen synthesis. His second argument concerns the curious fact that the vast majority of animals are able to biosynthesize vitamin C and are thus not dependent on an intake via food. Humans, primates, bats, guinea pigs are some of the exceptions. Pauling extrapolates that a typical animal weighing 70 kg would produce 10 g of vitamin C per day. This is much more than a human will normally take up via food, hence, according to Pauling, heavy supplementation is necessary. This line of thought is the source of his famous 10 g per day megadosage recommendation. Vitamin C and Cancer Linus Pauling Abram Hoffer Orthomolecular Medicine Andrew Saul