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Most people think “dialysis is dialysis,” but inside the machine, three different mechanisms are removing waste — and they behave very differently. 🔸 Hemodialysis: Uses diffusion. Dialysate has almost zero urea/creatinine and lower potassium, so small solutes move from blood → dialysate. Typical saturation? 40–50%. 🔸 Hemofiltration: Uses convection. Pressure pushes plasma water through the membrane, carrying not just small molecules but many middle molecules — like a river carrying both silt and leaves. Ultrafiltrate saturation? Close to 100%. 🔸 Hemoperfusion: Adsorption-based. No dialysate at all. Mainly for poisonings. But here’s the key question: If HF is so efficient, why isn’t everyone on HF? Because real-world practice is limited by: • The need for ultrapure substitution fluid (we infuse it straight into the bloodstream) • The filtration fraction, which must stay under 25–30% to avoid hemoconcentration With blood flow 300 mL/min and Hct 30%, plasma flow is only about 210 mL/min — meaning we can safely filter just 50–60 mL/min. HD, on the other hand, easily delivers 200–250 mL/min small-solute clearance. So HD remains the workhorse, HF and HDF are reserved for better middle-molecule clearance, and the art of dialysis is knowing what to use, when to use it, and why. #Dialysis #Hemodialysis #Hemofiltration #HDF #Nephrology #KidneyCare #DialysisEducation #NephroPhysiology #FluidTherapy #CriticalCareNephrology #RenalReplacementTherapy #DialysisMachine #MiddleMoleculeClearance #MedicalReels #DoctorsOfInstagram #TirupurKidneyDoc