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Micro 13: Bacterial Metabolism and Genetics

This episode enters the bacterial interior. Drawing from Murray’s chapter, it explores how bacteria generate energy, synthesise essential components, and adapt genetically to changing environments. Metabolism is framed not as biochemistry for its own sake, but as a determinant of growth conditions, tissue tropism, and laboratory identification. Aerobic versus anaerobic pathways, fermentation, nutrient requirements, and metabolic flexibility explain why some organisms thrive in oxygen-rich lungs while others dominate oxygen-poor tissues. Growth curves and environmental resilience underscore bacterial efficiency. The second half of the episode turns to genetics - chromosomal organisation, plasmids, transposons, and mechanisms of gene transfer including transformation, transduction, and conjugation. This is where adaptability becomes clinical consequence: antimicrobial resistance, virulence acquisition, and outbreak evolution. Conceptually, this chapter reveals bacteria as dynamic systems, capable of rapid genetic exchange and metabolic adjustment. Clinically, it explains why resistance spreads, why certain pathogens emerge unexpectedly, and why microbiology must always anticipate change. Key Takeaways Bacterial metabolism determines ecological niche and growth behaviour Aerobic and anaerobic strategies influence tissue infection patterns Plasmids and mobile genetic elements enable rapid adaptation Horizontal gene transfer accelerates resistance spread Genetic flexibility underpins bacterial survival and evolution This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit drmanaankarray.substack.com/subscribe (https://drmanaankarray.substack.com/s...)