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Cryotherapy: An Overview - Safely Remove Skin Tags Fast | Dermatologist What is Cryotherapy? Cryotherapy is a minimally invasive procedure that freezes and destroys skin lesions using extremely cold substances (cryogens). Also known as cryosurgery or cryoablation, it is a simple, cost-effective, and relatively safe treatment performed in outpatient settings. Common cryogens include: • Liquid nitrogen (-196°C) – Most commonly used in clinical practice • Carbon dioxide snow (-78.5°C) • Dimethyl ether and propane (DMEP) (-57°C) – Often available over the counter What Conditions Can Cryotherapy Treat? Cryotherapy is effective for various benign skin lesions, including: • Actinic keratoses • Seborrhoeic keratoses • Viral warts • Molluscum contagiosum • Skin tags It can also be used for superficial basal cell carcinoma (BCC) and in-situ squamous cell carcinoma (SCC) on the trunk and limbs, though recurrence is possible, requiring careful follow-up. Contraindications for Cryotherapy Cryotherapy is not recommended for: • Undiagnosed skin lesions • Melanoma • Dark-skinned patients (risk of pigmentation changes) • Lesions requiring histopathology • Areas with poor circulation • Patients with previous adverse reactions • Young children or unconscious patients • Conditions worsened by cold exposure (Raynaud’s disease, cold urticaria, cryoglobulinaemia, multiple myeloma) How Does Cryotherapy Work? Cryotherapy rapidly cools targeted tissue to sub-zero temperatures, leading to direct cell destruction. The thawing process further damages tissue by altering osmolarity. Liquid Nitrogen Cryotherapy Liquid nitrogen is applied using a cryospray, cryoprobe, or cotton-tipped applicator. Common application techniques: • Timed spot freeze (direct spray) – Standard method; liquid nitrogen is sprayed 1–1.5 cm above the lesion until an ice ball forms, covering the lesion and margin. The freeze is maintained for 5–30 seconds. A second freeze-thaw cycle may be used. • Paintbrush method • Rotary or spiral spray technique Carbon Dioxide Cryotherapy A frozen carbon dioxide snow or slush (mixed with acetone) is applied directly to the lesion. DMEP Cryotherapy DMEP is available in aerosol form and is often used for warts. A foam applicator is pressed against the lesion for 10–40 seconds, depending on size and location. Pros and Cons of Cryotherapy Cryotherapy is simple and relatively safe but may require multiple sessions, and pain can affect patient compliance. Effectiveness for Different Conditions • Actinic and Seborrhoeic Keratoses: • Actinic keratoses usually require a single freeze-thaw cycle (cure rates: 39%–83%). • Seborrhoeic keratoses may need longer treatment times or multiple cycles. • Viral Warts: • Clearance rates range from 39%–84% at three months, depending on size and hyperkeratosis. • Pre-treatment with keratolytics improves outcomes. • Malignant Lesions (BCCs and SCCs): • Cryotherapy is not first-line but an option for low-risk cases. • Requires multiple freeze-thaw cycles with 3–5 mm margins. • Recurrence rates vary (6%–34%), necessitating close monitoring. Potential Side Effects and Risks Immediate Effects: • Pain • Paraesthesia (tingling/numbness) • Swelling (especially near the eyes, lips, and forehead) • Headache • Blisters (clear or blood-filled) Delayed Effects: • Bleeding • Ulceration Other Complications: • Secondary infections (pain, swelling, pus, redness) – Managed with antiseptics or antibiotics • Rare nitrogen #drdermdiaries #skincare #lipoma #abscess #cyst #pimple #pimplepopper #skincancer #lipomaremoval #blackhead #cystpoping