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🐱🏍 Myxedema coma results in hyponatremia, cardiogenic shock, respiratory failure, and obtundation. Precipitating factors of hypothyroidism into myxedema coma are infections, exacerbations of comorbidities, trauma, and other stress inducers. Patients can have a nonspecific presentation initially. Address fluid balance and electrolyte replacement, vasopressors, antibiotics, in addition adequate ventilation. Adrenal insufficiency often overlaps with myxedema coma and stress dose hydrocortisone is coadministered with suspicion. While all thats going on, Low intracellular T3 is the underlying pathology. T4 is converted to T3; The American Thyroid Association recommends load with 200 - 400 mg IV, followed by 1.6 mcg/kg enteral and multipled by .75 if given IV. Liothyronine, isn’t available IV in the US and comes enteral. The ATA guidelines also recommend liothyronine 5 to 20 mcg, followed by 2.5 to 10 mcg every 8 hours.Consider lower end of dosing range for the brittle and those with extensive cardiac hx. For more PHARMFAX in the drug bank, check out another video on my page, share the #PHARMFAX with a friend, and I hope you learned something new. 🔮 Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Donate $5: www.pharmwyze.com//_paylink/AY78_L7r Social Links: links.pharmwyze.com DrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinbox Streaming Platforms: https://pharmwyze.hopp.to/podstreams Patreon: www.patreon.com/pharmwyze Paypal Donation: https://pharmwyze.hopp.to/paypaldonate PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsl... Not medical advice. Educational purposes only. No relationships to report. #emergency #ems #pharmacy #nursing #pharmacist #medicine #doctor #infection #toxicology #clinicalpearls #respiratory #dermatology #urology #nurse #cardiology #antibiotics #neurology #acs #pharmwyze #codebluedebrief #overdose #pharmacology #pharmacisst #meded #foamed #medshed #pharmacystudent #trauma #healthcare