Opioid Addiction: RNA Biology, Brain Inflammation & Psychedelic Therapy скачать в хорошем качестве

Opioid Addiction: RNA Biology, Brain Inflammation & Psychedelic Therapy

Send a text (https://www.buzzsprout.com/twilio/tex...) Gene regulation through RNAs, the neurobiology of opioid addiction, and how psychedelics affect drug-seeking by modulating inflammation and plasticity. Not medical advice. TOPICS DISCUSSED: • Gene regulation basics: DNA transcribes to RNAs, including non-coding types like microRNAs that inhibit mRNA translation into proteins, influencing up to 60% of the proteome. • Non-coding RNAs in neuroplasticity: MicroRNAs and circular RNAs regulate synaptic changes, with activity-induced ones like miR-485-5p linked to rapid responses in drug cue memory and addiction reinforcement. • Opioid addiction models: Rats self-administer heroin or fentanyl via levers, showing compulsive seeking; fentanyl’s higher potency drives faster learning but similar long-term effects to heroin when doses are equated. • Differences between opioids: Heroin and fentanyl both activate mu-opioid receptors for euphoria and dopamine release, but fentanyl lingers longer; no major behavioral differences in seeking once potency is matched. • Psilocybin’s effects on addiction: A single psilocybin dose post-abstinence reduces heroin-seeking in rats by dampening neuroinflammation in brain regions like the nucleus accumbens and prefrontal cortex. • Brain Inflammation: Opioids induce pro-inflammatory changes via cytokines like IL-17A and pathways like TNF-alpha, leading to glial activation and blood-brain barrier leaks; psilocybin counters this. • MicroRNA biomarkers: Blood microRNAs reflect gene expression patterns tied to disease states, with potential to predict opioid relapse risk, treatment response, or neonatal withdrawal severity non-invasively. • Future research: Ongoing work links psilocybin’s serotonin 2A activation to anti-inflammatory gene changes, plus human studies on microRNAs for personalized addiction treatments. ABOUT THE GUEST: Stephanie Daws, PhD is an associate professor at Temple University in the Center for Substance Abuse Research and Department of Neurosciences, where she researches mechanisms of drug-seeking behavior with a focus on opioids and psychedelics. RELATED EPISODE: • M&M 2 (https://mindandmatter.substack.com/p/...) | Psilocybin, LSD, Ketamine, Inflam Support the show (https://mindandmatter.substack.com/p/...) Health Products by M&M Partners: • SporesMD (https://sporesmd.com/?ref=mindmatter) : Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. • Lumen device (https://www.lumen.me/shop?fid=8731&di...) : Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. • AquaTru (https://aquatruwater.com/?oid2=50&aff...) : Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. • Seed Oil Scout (https://download.seedoilscout.com/xhL...) : Find restaurants with seed oil-free options, scan food products to see what they’re hiding, with this easy-to-use mobile app. • KetoCitra (https://santabarbaranutrients.com/pro...) —Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts (https://mindandmatter.substack.com/p/...)