A Conversation with an MPN Specialist: Myelofibrosis and Prefibrotic MF скачать в хорошем качестве

A Conversation with an MPN Specialist: Myelofibrosis and Prefibrotic MF

MPN Advocacy & Education International hosted a webinar with MPN Specialist Dr. Andrew Srisuwananukorn, The Ohio State University, to discuss and answer patient questions about myelofibrosis (MF) and prefibrotic MF. TIMESTAMPS 00:00 A Conversation with an MPN Specialist: Myelofibrosis and Prefibrotic MF 22:14 I was diagnosed 2 years ago JAK2+ PV following a massive DVT. In 2025, I’m diagnosed as ‘transitioning to MF’ with fibrosis 1-2 on scale of 3 and taking Jakafi. WBC etc are now ‘normal’. Can I expect this normalization to continue or should I expect a fibrotic breakout at some point? 25:33 Does having a JAK2 mutation and a DMNT3A mutation increase the risk of progression to MF or AML? Can anything be done to stop that? 26:58 What's your opinion on when to treat or not treat newly diagnosed MPN patients? 30:24 During pregnancy, what treatment do you recommend? 31:29 Is there any documentation on patients that have been able to reverse fibrosis? 32:18 Is Jakafi not effective at reducing symptoms for prefibrotic MF, is adding an interferon a reasonable approach? 34:16 I am 75 years old with PV, diagnosed in 2018, and currently taking HU. My blood counts are controlled but wondering if you recommend switching to BESREMi with the hope of slowing progression or are the possibly side effects not worth it at this age? 36:26 I am an ET patients with CALR deletion mutation. A couple years ago had a bone marrow biopsy that showed reticulin fibrosis but little collagen fibrosis. What do the different fibrosis factors mean? 37:49 Are there any trends you are seeing in the patient population for ET, PV, and MF? 42:06 I was rediagnosed from ET to pre-PMF with the MPL mutation taking pegasys. I'm wondering if taking BESREMi may be better option and/or would like to learn more about the HOPE clinical trial you mentioned earlier? 44:45 Are there any studies or examples of people that have been able to get their bone marrow to return to blood production and take the pressure off of the spleen?