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This activity has been supported by sponsorship from Roche Products Limited. The sponsor has had no control over the educational content of this activity. Case: A 32-year old neurology trainee is referred to you for an opinion. She has a long history of atypical migraine without any aura. A colleague who saw her as a favour ordered an MRI scan to exclude any intracranial pathology. The MRI has come back abnormal with multiple high-signal white matter lesions typical of demyelination. Two of the lesions, one in the deep white matter of the right parietal lobe and a second juxtacortical lesion in the left frontal lobe, enhanced after gadolinium administration. There is no history of any previous neurological symptoms. Objective: To review the diagnosis, epidemiology and management of radiologically-isolated syndrome. Speakers: • Chair: Dr Camilla Blain, Consultant Neurologist, St George’s University Hospitals NHS Foundation Trust • Dr Audrey Sinclair, Consultant Neuroradiologist, St George’s University Hospitals NHS Foundation Trust • Amy Harbour, Multiple Sclerosis Nurse Specialist and Clinical Lead, Southern Health NHS Foundation Trust