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Watch the Full Video at https://www.jove.com/v/51438/investig.... Investigating Protein-protein Interactions in Live Cells Using Bioluminescence Resonance Energy Transfer - a 2 minute Preview of the Experimental Protocol Pelagia Deriziotis, Sarah A. Graham, Sara B. Estruch, Simon E. Fisher Max Planck Institute for Psycholinguistics, Language and Genetics Department; Donders Institute for Brain, Cognition and Behaviour,; Interactions between proteins are fundamental to all cellular processes. Using Bioluminescence Resonance Energy Transfer, the interaction between a pair of proteins can be monitored in live cells and in real time. Furthermore, the effects of potentially pathogenic mutations can be assessed. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments