Скачать с ютуб Antibodies (Origin, Components, Domains, IgG, IgM, IgA, IgD, IgE) +TABLE - Immunology в хорошем качестве

Antibodies (Origin, Components, Domains, IgG, IgM, IgA, IgD, IgE) +TABLE - Immunology

This video is part 2 of Acquired immunity - Antibodies Content 0:00 Introduction 0:06 Where do Antibodies Come From? 5:31 Components of an Antibody 7:32 Domains 8:37 IgG 9:50 IgM 11:53 IgA 13:39 IgD 14:22 IgE 15:17 Differences Between Antibodies 15:56 Table to Memorize ------------------------------- 🫀 Join:    / @taimtalksmed   📷 Follow my IG:   / taimtalksmed   💝 Donation link: https://www.buymeacoffee.com/taimtalk... ------------------------------- -------------------------------------------------------------------------------- All information in my immunology videos are from: Book: Immunology, Eighth Edition by David Male, Jonathan Brostoff, David Roth and Ivan Roitt Additional research in PubMed University lecture materials -------------------------------------------------------------------------------- Antibodies: Plasma proteins Where they come from: 1. B-cell (with BCR - IgG/D) bind to antigen 2. Present it on MHC II 3. APC activates a naive Th cell through TCR (CD4 and CD3), B7/CD28 and IL-4 receptor 4. Naive T helper cell secretes IL2 (autocrine) 5. Becomes an active Th2 6. Th2 helps active B-cell through CD40L/CD40 and T cell receptor. 7. IL-4, IL-5, IL-8, IL-10, IL-2, IFN gamma released depending on what type of antibody is needed. Components of an Antibody: Has: Light Chain Heavy Chain Variable Part Constant Becomes: VL, Vh, CL, Ch1, Ch2, Ch3 CL-Ch1 Connected through disulfide bonds two parts of antibody connected through a Hinge which give the antibody motility divided into Fab (fragment antigen binding) and Fc (Fragment crystalizable region) Antibody Domains: Variable region - Antigen binding sites Ch1 region - Determine Allotype Ch2 region - Binds Complement Ch3 region - Binds Cells Variants of chains: Light Chain: Lambda Chain Kappa Chain Heavy Chain: Gamma Chain (IgG) My Chain (IgM) Alpha Chain (IgA) Delta Chain (IgD) Epsilon Chain (IgE) Functions of IgG: Exists as: Monomeric (plus subtypes) Amount in Plasma: 75% IgG is only antibody that pass through placenta. so we get igG from mothers. Direct Opsonization Activate Complement System IgG responsible for the secondary response in humoral immune response because memory B-cells are made to produce IgG Functions of IgM: Pentameric (with a J-Chain) and Monomeric on B-cells ''Youngest Class'' since a fetus can produce them. IgM reacts as the primary response, but no memory as they are produced by T-cell independent B cell proliferation Complement activation Functions of IgA: Dimeric (J-chain), Monomeric and Trimeric Found at mucosal entry Alpha plasma cells secretes IgA. IgA binds to epithelium through poly IgA receptors and transported through cytoplasm through endocytosis and sent out through proteolytic cleavage Many microorganisms can cleave IgA Functions of IgD: Under 1% in blood Localized on surface of B-cells Monomeric Functions of IgE: Very low amount in blood Monomeric Mast Cell Responsible for Type 1 hypersensitivity. Made after sensitization. Increase amount of IgE during allergic diseases and parasite infections. Differences between Immunoglobulins: Idiotypic differences: Differ in variable region Isotypic Differences: Antibodies differ in constant region Allotypic Differences: Difference between alleles of same constant gene