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Descemet's Membrane Endothelial Keratoplasty (DMEK) is a type of corneal transplant surgery that involves replacing the damaged endothelial layer of the cornea with healthy donor tissue. Here are some key points about DMEK: What is DMEK? DMEK involves the selective removal of the patient's damaged Descemet membrane and endothelium, followed by transplantation of a thin layer of donor tissue that includes the Descemet membrane and endothelial cells. Indications DMEK is typically indicated for conditions such as: Fuchs' Endothelial Dystrophy: A genetic condition that causes the endothelial cells to deteriorate. Posterior Polymorphous Corneal Dystrophy: A rare genetic disorder affecting the corneal endothelium. Pseudophakic Bullous Keratopathy: Swelling and blistering of the cornea after cataract surgery. Iridocorneal Endothelial (ICE) Syndrome: A disorder that affects the corneal endothelium and can lead to corneal swelling. Procedure Anesthesia: The procedure is performed under local anesthesia with sedation. Corneal Incision: A small incision is made in the cornea. Removal of Damaged Tissue: The damaged Descemet membrane and endothelium are carefully removed. Donor Tissue Preparation: The donor tissue is prepared and inserted into the anterior chamber of the eye. Air Bubble: An air bubble is injected to hold the donor tissue in place against the cornea. Benefits Rapid Visual Recovery: Patients often experience quick improvement in vision. Minimal Interface: Since only the innermost layers are transplanted, there is less optical interface, leading to better visual outcomes. Lower Rejection Rates: The risk of graft rejection is lower compared to full-thickness transplants. Risks Graft Rejection: Although lower, there is still a risk of the body rejecting the donor tissue. Graft Edge Lift: The thin graft can sometimes lift from the cornea, requiring additional procedures. Postoperative Care: Patients need to maintain a specific posture (looking up) to keep the air bubble in place until it is absorbed #Keratoplasty