OsteoBites | Barcoding metastatic osteosarcoma to identify chemoresistance mechanisms. скачать в хорошем качестве

OsteoBites | Barcoding metastatic osteosarcoma to identify chemoresistance mechanisms.

Dr. Aafrin Pettiwala from UCSF joins us on OsteoBites to discuss her OutSmarting Osteosarcoma funded work on identifying mechanisms of chemoresistance in metastatic osteosarcoma using molecular barcoding. The presentation covers how intratumoral heterogeneity drives chemoresistance and metastasis in osteosarcoma by using lineage tracing (CaTCH) and patient-derived xenograft models. She has identified resistant and metastatic cell subpopulations and their molecular vulnerabilities, and further research seeks to uncover new therapeutic targets to improve treatment outcomes for metastatic osteosarcoma patients. Dr. Pettiwala earned her PhD in Cancer Biology from Institut Curie in Paris, France, where she studied therapeutic resistance and phenotypic plasticity in brain tumors. Her doctoral work focused on uncovering the molecular mechanisms that allow cancer cells to adapt and evade treatment. Currently, Aafrin is a postdoctoral researcher in the lab of Dr. Alejandro Sweet-Cordero at the University of California, San Francisco (UCSF). Her research centers on understanding chemotherapy resistance in metastatic osteosarcoma, with an emphasis on clonal dynamics, tumor evolution, and lineage tracing using high-throughput barcoding technologies. ---- You're not alone. We're here for you. 💙 ---- What are OsteoBites? OsteoBites are weekly webinars and podcasts presented by MIB Agents, an organization dedicated to Making It Better for children with osteosarcoma. We offer education, support, and advocacy for families facing this challenging disease. Learn more about our mission and programs at https://www.mibagents.org --- --- Want to support our mission? Donate here: https://give-usa.keela.co/embed/YAipu... ---- Stay updated with the latest news and events: https://www.mibagents.org/how-to-help...